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KMID : 0361120060200020181
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Korean Journal of Transplantation
2006 Volume.20 No. 2 p.181 ~ p.186
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Experience of Simultaneous Pancreas and Kidney Transplantation in Seoul National University Hospital
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박재우
하종원/이정훈/강진모/정선경/김은만/이호선/김연수/조영민/박경수/안규리/김상준
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Abstract
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Purpose: Aim of this study is to review the simultaneous pancreas and kidney transplantation (SPK) cases performed in Seoul National University Hospital for DM nephropathy patients. Methods: Medical records of the SPK recipients from April 2002 to February 2006 were reviewed and analyzed retrospectively. Results: There were 10 cases of SPK transplantation in SNUH from April 2002 to February 2006, which were composed of 8 type II DM patients and 2 type I DM patients. We experienced 1 operative mortality case and 3 acute rejection cases. All the acute rejection cases were recovered by steroid pulse therapy. We performed two graft pancreatectomy operations due to CMV infection followed by duodenal perforation and severe graft pancreatitis with pancreatic leakage. With the exception of 1 mortality case and 2 graft loss cases, all 7 patients stopped insulin and oral hypoglycemic agent and are keeping blood glucose level within normal range. Conclusion: Although patient follow-up is limited up to four years, SPK recipients are free from insulin use and show
good graft functions. SPK could be a good treatment modality for insulin dependent type II DM nephropathy patients. (J Korean Soc Transplant 2006;20:181-186)
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KEYWORD
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Pancreas transplantation, Kidney transplantation, Diabetes mellitus, ESRD, end-stage renal disease, Immunosuppressive agents
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